bioRxiv· Qoku, A., Ullrich, N., Miranda, F., Rosenthal, T., Keil, A., Vowinckel, J., Dueker, M. S., Ruengeling, S., Rosen, L.-A., Gaetje, F. B., Zielke, M., Tucholski, T., Dressler, F. F., Kueffer, S., Koenig, A. O., Ellenrieder, V., Ghadimi, M., Reuter-Jessen, K., Rinner, O., Grabe, N., Conradi, L.-C., Buettner, F., Stroebel, P., Bohnenberger, H. ·· 19 hours agoPickScore61
A clinically annotated proteomic and histological resource of 1,000 colorectal cancers
In brief
A research team released a multimodal open resource covering 1,000 treatment-naive colorectal cancer cases, integrating deep proteomics, targeted genomics, whole-slide pathology and clinical follow-up. From the proteome, the study defines six subgroups and resolves the chromosomally unstable class into three functional subgroups, including an indolent subgroup with favorable prognosis and a rare, previously unrecognized subgroup with poor prognosis.
Why it matters
The resource integrates multi-omics, clinical follow-up and whole-slide images across 1,000 treatment-naive colorectal cancers, and its multi-protein classification transfers to an independent cohort as an open reference.
Source: bioRxiv