Cachexia doesn’t just waste muscle — it kills ICI response.
@DrR_DUNNE
#AACR26

Same TME mediators (IL-6, PGE2, TNF-α) driving wasting are driving immunotherapy resistance. Cachexic patients: 2.3 mo PFS vs 12.0 mo across 4 studies .

PGE2 is elevated in cachexic patients.