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Mario Balsa· @MarioBalsaMD · X·· 2 days agoScore70

pembrolizumab

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🚨#ESMO26 IOV-COM-202: bringing TILs upfront! Lifileucel + pembrolizumab in ICI-naïve advanced melanoma.

💥 ORR 62.5% | CR 29.2%
▪️ mPFS 19.8m | mDOR NR | 13/15 responses ≥12m

Now TILVANCE-301 has to advance the signal 👀

@OncoAlert @OncoReporte @myESMO @_SEOM @GrupoMelanoma

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Conference abstracts
1239Omatched by Proffered paper: Gynaecological cancers

NRG-GY020: Phase III randomized trial of radiation +/- MK-3475 (pembrolizumab) for newly diagnosed early-stage high intermediate risk (HIR) mismatch repair deficient (dMMR) endometrioid endometrial cancer

https://esmocongress.esmo.org
2071Omatched by Proffered paper: Melanoma and other skin tumours

STARBOARD phase 3: A randomized, double-blind study of first-line (1L) encorafenib (enco), binimetinib (bini), and pembrolizumab (pembro) vs placebo (pbo) and pembro for unresectable locally advanced or metastatic BRAF V600-mutant melanoma

https://esmocongress.esmo.org
2072Omatched by Proffered paper: Melanoma and other skin tumours

Efficacy and safety of lifileucel and pembrolizumab in patients with immune check point inhibitor-naïve advanced melanoma: Final results from IOV-COM-202 study

https://esmocongress.esmo.org
2217RONCT04746300matched by Rapid oral: Genitourinary tumours, prostate, penile and testis

Updated results from the phase 1b/2 KEYNOTE-365 cohort I: Pembrolizumab (pembro) + carboplatin and etoposide chemotherapy (chemo) or chemo alone for neuroendocrine prostate cancer (NEPC)

https://esmocongress.esmo.org
2683Pmatched by NSCLC, metastatic

First-line (1L) olomorasib + pembrolizumab in KRAS G12C-mutant NSCLC: Updated results from LOXO-RAS-20001 and SUNRAY-01

https://esmocongress.esmo.org

Source: Mario Balsa · x.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org