mp.weixin.qq.com·· 11 hours agoPickScore79
Nature Cell Biology study shows GITR signalling reactivates COTL1high NK cells and may overcome ICB resistance in tsMHC-I-impaired tumours
In brief
A Nature Cell Biology study shows that PD-1/PD-L1 blockade releases SHP-1-mediated inhibition of GITR-STAT5 signalling, reactivating COTL1high NK cells. Their IFN-γ in turn upregulates tumour tsMHC-I and strengthens CD8+ T cell responses.
Why it matters
The study integrates clinical cohorts, animal models and multi-omics to define the GITR-STAT5-COTL1high NK cell pathway that upregulates tsMHC-I.
Source: mp.weixin.qq.com · mp.weixin.qq.com