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UCLA Backus Team Develops SEE-CITE Silyl Ether Chemoproteomics Method for Small-Molecule Binding-Site Discovery
In brief
Keriann M. Backus's team at UCLA reports in Nature Chemistry the development of SEE-CITE (Silyl Ether Enabled Chemoproteomic Interaction and Target Engagement), a method for discovering small-molecule binding sites.
Why it matters
SEE-CITE moves photoaffinity labeling from protein-level to residue-level localization and extends the FragPipe scoring algorithm for direct reuse in probe screening and off-target discovery workflows.
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