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Urs Weber MD· @UrsWeberMD · X·· 1 day agoScore70
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SAFFRON provides further evidence for 2 key concepts:
1. Continue osimertinib post-progression.
2. Target MET overexpression.
My main concern with this particular approach is patient selection. How many patients have c-MET IHC 3+ >90%?
@EGFRResisters @myESMO #ESMO26

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引用@
Presented at #ESMO26: In patients with 𝘌𝘎𝘍𝘙-mutated and MET-altered non–small-cell lung cancer that had progressed during osimertinib therapy, osimertinib plus savolitinib (a MET tyrosine kinase inhibitor) led to longer survival than platinum–pemetrexed. Full phase 3 SAFFRON trial results: https://nej.md/4hXdueb @myESMO
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Source: Urs Weber MD · x.com

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