reddit.com· r/science · Reddit·· 21 hours agoPickScore77
Sustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling | Nature Neuroscience
In brief
IHCH-8134, a structure-guided 5-HT2AR–β-arrestin biased agonist, produced sustained antidepressant-like effects in mice. Cumulative, AUC-dependent β-arrestin signaling was identified as the key driver.
Why it matters
It attributes sustained antidepressant-like effects to β-arrestin signaling and hallucinogenic effects to Gαq signaling, laying out a mechanistic basis for biased agonist design.
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