WeChat· 国际科学·· 6 hours agoPickScore76
Guangzhou Medical University team reports SLC52A2-mediated tumor competition for vitamin B2 drives T cell ferroptosis in Cell
In brief
Yingjie Bian's team reports in Cell that tumor cells preferentially take up vitamin B2 from the microenvironment via SLC52A2, creating metabolic competition with T cells and driving their ferroptosis. Knocking out SLC52A2 in tumors restored T cell antitumor function without affecting tumor proliferation itself.
Why it matters
The paper defines the SLC52A2 mechanism by which tumors compete with T cells for vitamin B2, and knocking out the transporter restores T cell function without affecting tumor proliferation.
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