🔥 #ESMO26 INTerpath-001, full data (now yes)
On top of RFS HR 0.58 and DMFS HR 0.62:
• Manufacturing success >99%
• >90% of patients got the maximum 34 neoantigens
🔍 Practice-changing? For a population, yes. Two things still to prove:
• Can an mRNA strategy rescue patients primary refractory to neoadjuvant ipi-nivo (no pathologic response)?
• Will it move OS in stage II-IIIB too?
Resuls in @NEJM soon
@myESMO @OncoAlert @Larvol @_SEOM
#Melanoma #Immunotherapy
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
https://esmocongress.esmo.orgINTerpath-001
https://esmocongress.esmo.orgSource: Yago Garitaonaindía · x.com
