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Yago Garitaonaindía· @YGaritaonaindia · X·· 15 hours agoScore70

INTERPATH-001

Body

🔥 #ESMO26 INTerpath-001, full data (now yes)

On top of RFS HR 0.58 and DMFS HR 0.62:
• Manufacturing success >99%
• >90% of patients got the maximum 34 neoantigens

🔍 Practice-changing? For a population, yes. Two things still to prove:
• Can an mRNA strategy rescue patients primary refractory to neoadjuvant ipi-nivo (no pathologic response)?
• Will it move OS in stage II-IIIB too?

Resuls in @NEJM soon

@myESMO @OncoAlert @Larvol @_SEOM

#Melanoma #Immunotherapy

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Conference abstracts
LBA1matched by Presidential Symposium I

INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)

https://esmocongress.esmo.org

Source: Yago Garitaonaindía · x.com

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