Medicinal chemistry beyond KRAS: CDK2, WEE1, SERD
zedoresertib · A WEE1-path molecule on the floor
#AACR26 | Gyn Onc
#MYTHIC trial (CT022) - first-in-human data for #WEE1i #zedoresertib + #PKMYT1i #lunresertib in genomically selected solid tumors (#CCNE1 amp, #FBXW7 mut, #PPP2R1A mut). These alterations drive replication stress and have NO approved targeted therapy - 24.5% of
Heat 27 · 19 likes · 0 replies · 8 reposts
Timothy A. Yap, Rahul Aggarwal, Elisa Fontana, Martin Hojgaard, Benedito A. Carneiro, Linda Duska, Patricia LoRusso, Siddhartha Yadav, Stephanie Lheureux, Cara Mathews, Ryan H. Moy, Nehal Lakhani, Mia Weiss, Joan Tymon-Rosario, Gerardo Colon-Otero, Ignacio Garrido-Laguna, Elisabeth K. Lee, Esteban Rodrigo Imedio, Jonathan Wessen, Luke Piggott, Vito Dozio, Noemie Luong, Christophe Mas, Alison M. Schram
Read the abstract →Source: Mali Barbi, MD MSc | Breast & Gyn Oncologist · x.com