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FHD-909

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Platform layer: molecular glues, spatial omics, AI

FHD-909 / MRT-55811 / MR-2088 · Epigenetic / ULK tool molecules on the floor

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At the 2026 @AACR Annual Meeting, we presented new preclinical data for our selective SMARCA2 inhibitor, FHD-909, and for Selective CBP, EP300, and ARID1B degrader programs. See the findings: https://t.co/eyKPNmKe2C

#AACR26 https://t.co/hX3PN7xifm

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Conference abstracts
3500matched by 代号 EP300
Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

Annika Gustafson, Stephanie Nance, Berkley Gryder, Noha A. Shendy, Lars Wick, Grace McKay-Corkum, K. Elaine Ritter, Stephen Connor Purdy, Arthur R. Wolin, Sheera R. Rosenbaum, Sabateeshan Mathavarajah, Nickerson A. Demelfi, Yueyang Wang, Yang Zhang, Mark W. W. Zimmerman, Anoop M. Kavirayani, John Hardin, Alexander LaVeck, Xiang Wang, Neekesh V. Dharia, Andrew Hong, Guillaume Kugener, Jesse S. Boehm, Jennifer Roth, Javed Khan, Francisca Vasquez, Kristin B. Artinger, Rui Zhao, David M. Langenau, Jun Qi, Kimberly Stegmaier, Heide L. Ford, Adam D. Durbin, Brian J. Abraham

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4024matched by 代号 EP300
Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300

Ian Delahunty, Stephanie Nance, Yang Zhang, Francois Lamoureux, Qi Liu, W. Charlie Wright, K. Elaine Ritter, Noha A. Shendy, Benedicte Brounais, Sandra Kietlinska, Barbara De Kegel, Matthew G. Rees, Mustafa Kocak, Ashish B. George, Anoop M. Kavirayani, Paris P. Prinsen, Yousef Khashana, Melissa M. Ronan, Jennifer Roth, Alejandro Sweet-Cordero, Xiaotu Ma, Lillian M. Guenther, Paul Geeleher, Benjamin Ory, Jun Qi, Brian Abraham, Adam D. Durbin

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