bioRxiv Genomics· LeMay, S. W., Harpak, A. ·· 21 hours agoPickScore59
Collapsed Site Coalescent Facilitates Detection of Adaptive Divergences Between Segmental Duplicates
In brief
LeMay and Harpak propose the Collapsed Site Coalescent (CSC) model, which collapses each pair of paralogous sites into a pseudo-site with its own genealogy, to support ARG inference for segmental duplications.
Why it matters
The CSC model collapses paralogous site pairs into pseudo-sites with self-contained genealogies; simulations yield IGC parameter estimates close to true values and identify adaptively diverged regions protected from IGC.
