youtube.com· GLOBAL IMMUNOTALKS · YouTube·· 8 hours agoPickScore78
David Sancho Lecture: NGR1 Marks CDC1 Dendritic Cell Cross-Presentation and Macrophage Metabolic Adaptation
In brief
David Sancho of CNIC found that the C-type lectin NGR1 (PlxnA), via Syk signaling, marks the CDC1 dendritic cell subset responsible for MHC I cross-presentation. Loss of NGR1 impairs cross-presentation of OVA and vaccinia antigens in vitro and in vivo.
Why it matters
The lecture separates dendritic cell activation from antigen presentation and links CDC1 cross-presentation, checkpoint therapy and macrophage metabolism in mouse models.
Source: youtube.com · youtube.com