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Oriol Mirallas MD· @DrMirallas · X·· 2026-04-20Score60

#PDAC

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KRAS / RAS targeting: from platform to Phase 3

daraxonrasib ± GnP · mono ORR 47%; +GnP ORR 55%, DCR 90%

Body

Presidential session #2 #AACR26

Dr. Mischel
@StanfordMed

Advancing cancer science to save lives

@carlhjune

@Penn

CAR-T applications solid tumors
Promising delivered locally #GBM
How to tune with #CAE for #PDAC
Promising #CART #solidtumors

@AACR

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Heat 14 · 8 likes · 1 reply · 5 reposts

Conference abstracts
CT303NCT05410145matched by 药名 cetuximab
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

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LB407NCT05379985NCT06445062matched by 药名 daraxonrasib
Daraxonrasib plus chemotherapy (CT) as first-line (1L) treatment for patients (Pts) with metastatic pancreatic adenocarcinoma (mPDAC)

Brian M. Wolpin, Benjamin L. Musher, Gulam A. Manji, Wungki Park, Alexander Spira, Nilofer Azad, Vaia Florou, Tiago Biachi De Castria, Mark H. O'Hara, Erkut Borazanci, Aparna Parikh, John Strickler, Joel Randolph Hecht, Shubham Pant, Shiraj Sen, E. Gabriela Chiorean, W. Clay Gustafson, Hina Patel, Vidya Seshadri, Yan Zheng, Davendra Sohal

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Source: Oriol Mirallas MD · x.com

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