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AACR Annual Meeting 2026

April 17–22, 2026 · San Diego · 2418 items

← KRAS / RAS targeting: from platform to Phase 3

#PDAC

Clinical trial

4 people · 5 posts · 3 abstracts

Records
Drug / trialReadoutSetting
daraxonrasib ± GnPdaraxonrasib#PANCREATICCANCER#PDACmono ORR 47%; +GnP ORR 55%, DCR 90%1L mPDAC · Phase 1
Other cases in this chapter
  • daraxonrasibmOS 13.2 vs 6.7 mo, HR 0.40
  • zoldonrasibORR 52%, DCR 93%, mPFS 11.1 mo; ctDNA clearance 73%
  • VS-7375NSCLC ORR 68.8% (n=16); pancreas ORR 58%
  • elisrasibG12Ci-naive NSCLC ORR 59.5%; pretreated 32.3%
  • RM-055Active in daraxonrasib-resistant and RAS-amplification models
Evidence
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

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Daraxonrasib plus chemotherapy (CT) as first-line (1L) treatment for patients (Pts) with metastatic pancreatic adenocarcinoma (mPDAC)

Brian M. Wolpin, Benjamin L. Musher, Gulam A. Manji, Wungki Park, Alexander Spira, Nilofer Azad, Vaia Florou, Tiago Biachi De Castria, Mark H. O'Hara, Erkut Borazanci, Aparna Parikh, John Strickler, Joel Randolph Hecht, Shubham Pant, Shiraj Sen, E. Gabriela Chiorean, W. Clay Gustafson, Hina Patel, Vidya Seshadri, Yan Zheng, Davendra Sohal

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Floor
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CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org