Curtis Rink, Tom Clough, Ellen Watts, Folake Orafidiya, Marine Houée, Sophie Brown, Victoria Juskaite, Gezim Lahu, Ruairidh Edwards, Karen Campbell, Dave Liebowitz, David Jones, Francis Wilson, Michelle Morrow
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AACR Annual Meeting 2026
April 17–22, 2026 · San Diego · 2418 items
← Next-generation ADCs: payload innovation
AVA6103
3 people · 4 posts · 1 abstract
Heat trend for this story
Heat now 1·Peak in the comparable set 1 (Apr 22 09:00)·Change over 24h in the comparable set –·Participants now 1
Participants counted1
Heat over time
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Records
| Drug / trial | Readout | Setting |
|---|---|---|
| AVA6103 / pan-RAS ADCAVA6103CLDN18 | Tricomplex pan-RAS as payload | Among the floor’s strongest ADC threads |
- Whether a pan-RAS ADC payload has a therapeutic window that survives first-in-human.
Other cases in this chapter
- T-DXd + pertuzumabPFS HR 0.56 (40.7 vs 26.9 mo)
- olaparib + T-DXdConfirmed PR 42.9%, mDOR 11.2 mo (n=28)
- risvutatugB7-H3 ADC, floor ORR ~47%
- zanidatamab 新辅助No-chemo pCR 30%, HER2 down 56%
Evidence
5846
AVA6103 is a FAP-enabled pre|CISION®peptide-drug conjugate delivering sustained release of exatecan in the tumor microenvironment with potent antitumor activityFloor
x.com@Score6060 x.com@Score6060
MBC Advocate@MBCadvocateScore6060 Best news ever! AVA6103 includes ER+ metastatic breast cancer! A major step forward!
MBC Advocate@MBCadvocateScore6060 Congrats Avacta! This is fantastic news!