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AACR Annual Meeting 2026

April 17–22, 2026 · San Diego · 2418 items

← KRAS / RAS targeting: from platform to Phase 3

KRAS

Clinical trial

51 people · 66 posts · 5 abstracts

Heat trend for this story

Heat now 4·Peak in the comparable set 5 (Apr 23 04:00)·Change over 24h in the comparable set –·Participants now 6

Participants counted6
0246
Heat over time
0246Apr22Apr23Apr23Apr23

Participants counted above, heat below. The trend compares only the participants observed in full throughout, so its set can be smaller than the heat figure itself. Move the pointer or click the chart for an hour's reading; the left and right arrow keys work too.

First-generation G12C drugs (sotorasib, adagrasib) bind KRAS in the off state. After treatment, RTK feedback reloads KRAS into the on state.

Other cases in this chapter
  • daraxonrasibmOS 13.2 vs 6.7 mo, HR 0.40
  • daraxonrasib ± GnPmono ORR 47%; +GnP ORR 55%, DCR 90%
  • zoldonrasibORR 52%, DCR 93%, mPFS 11.1 mo; ctDNA clearance 73%
  • VS-7375NSCLC ORR 68.8% (n=16); pancreas ORR 58%
  • elisrasibG12Ci-naive NSCLC ORR 59.5%; pretreated 32.3%
  • RM-055Active in daraxonrasib-resistant and RAS-amplification models
Evidence
CT129
Preliminary results from a Phase 1a/b dose-escalation and expansion trial of the pan-RAF-MEK molecular glue NST-628 in patients (pts) with advanced or refractory RAF, KRAS, and NRAS-mutant solid tumors

Ahmad A. Tarhini, Monica Chen, Jia Liu, Varun Monga, Victoria Atkinson, Sarina A. Piha-Paul, Bartosz Chmielowski, Benjamin Herzberg, Charlotte Lemech, Prachi Bhave, Ganessan Kichenadasse, Gerald Falchook, Janice Mehnert, Andrae Vandross, Mohamad Salkeni, Meredith McKean, David Wages, Ann Marie Kennedy, Meagan B. Ryan, John Clark, Abdulaziz Nanah, Michael J. Fossler, Philip Komarnitsky, Igor Puzanov

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CT303NCT05410145
Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study

Kanwal Pratap Raghav, Jun Zhang, Myung-Ah Lee, Jingdong Zhang, John Park, Yanqiao Zhang, Susana Rosello Keranen, Byoung Chul Cho, Herbert Ho Fung Loong, Cheng Chen, Huan Li, Shaonan Wang, Yandong Shen, Zifei Fan, Qian Chen, Hui Wang, Jing Zhang, George Zhi Jian Chen, Jayesh Desai, Antoine Hollebecque

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Floor
Apr 21Tue
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CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org