KRAS / RAS targeting: from platform to Phase 3
First-generation G12C drugs (sotorasib, adagrasib) bind KRAS in the off state. After treatment, RTK feedback reloads KRAS into the on state.
@DocSacher
@pmcancercentre
answers a key question - "Does the world need another KRAS G12C OFF inhibitor?" #AACR26
Key benchmarks for any new G12Ci:
Primary resistance & ORR
Durability of response
Toxicity profile (autoimmune hepatotoxicity!)
Activity in hard-to-treat
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Kayla Tyskiewicz, Markus Hippich, Tristan Cates, Gervaise Henry, Gilad Silberberg, Nicole Spanburg, Madeline Westcott, Daniel Ciznadija, Michael Boice, Paul Heverly, Frank Smith, Marianna Zipeto, Stefano Cairo, Sebastian Brabetz
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Read the abstract →Source: LUNGevity Foundation · x.com