Cell· Xiao Zhang, Guangyao Lai, Xiangyu Guo, Wen Ma, Yue Yuan, Han Zhang, Bo Zhang, Peng Fan, Xingyuan Liu, Pengcheng Guo, Juan An, Jinxiu Li, Keke Huang, Xiaoyan Li, Jing Zuo, Liang Wu, Shuncheng Shangguan, Feng Yu, Yuchen Xiang, Yuebei Hu, Yuxuan Liu, Yunting Huang, Yiting Lin, Dajian He, Mingtian Pan, Laiqiang Chen, Bang Li, Jiawei Zhang, Qintian Guo, Weili Yang, Peng Yin, Shihua Li, Xiaolan Zhang, Tao Yang, Xiaofeng Wei, Yuan Lv, Baoming Qin, Xiaobing Qing, Qiuting Deng, Yaling Huang, Chang Liu, Lei Han, Shiping Liu, Dajiang Qin, Zhen Liu, Yi Zhou, Liang Qiao, Chengyu Li, Yanxiao Zhang, Zunpeng Liu, Yan Li, Paulina Carriba, Mara Dierssen, Giacomo Volpe, Simon Graf, Ian Ferenc Diks, Matthias Flotho, Rafal P. Krol, Jan Mulder, Chaiyaboot Ariaychet, Nattiya Hirankarn, Andrew P. Hutchins, Andreas Keller, Patrick H. Maxwell, David C. Rubinsztein, Pura Muñoz-Cánoves, Xiaolei Liu, Hung-Fat Tse, Muming Poo, Bo Wang, Longqi Liu, Ying Gu, Jun Xie, Xun Xu, Xiaojiang Li, Chuanyu Liu, Yiwei Lai, Miguel A. Esteban, Mingyuan Liu·· 2026-08-18评分49
跨越成年猕猴寿命的多模态脑细胞图谱
Multimodal brain cell atlas across the adult macaque lifespan
导读
一项研究构建了包含295万个细胞核的多模态单核图谱，覆盖八个猕猴脑区并横跨整个成年寿命期。该图谱揭示了衰老过程中脑细胞存在区域特异性和共享的脆弱性模式。这一框架为剖析灵长类大脑衰老、长寿和神经退行性变的分子程序提供了基础。
来源：Cell · cell.com