Cell· Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug, Wei Gai, Katherine J. Surridge, Elizabeth Moussikhina, Kendrick H.V. Nguyen, Marta Sanz-Murillo, Robert Callahan, Erica Xiong, Delisa Ramos, Lawrence Zhu, Verena Dederer, Sebastian Mathea, Janet Iwasa, Stefan Knapp, Kevan M. Shokat, Samara L. Reck-Peterson, Andres E. Leschziner·· 2026-08-10精选评分59
LRRK2激酶激活与自抑制的结构基础
The structural basis for LRRK2’s activation and autoinhibition
导读
研究发现LRRK2的ROC GTPase作为核苷酸依赖性分子开关调节其激活和自抑制，并揭示了部分帕金森病突变如何破坏这一调控开关。
来源：Cell · cell.com