Cell· Deepali L. Kundnani, Yeunsoo Lee, Taehwan Yang, Tyler P. Warner, Francisco Martinez-Figueroa, Tejasvi Channagiri, Penghao Xu, Ryan A. Eckerty, Mo Sun, Supreet Randhawa, Youngkyu Jeon, Stefania Marsili, Gary Newnam, Yilin Lu, Miharu Yasumuro, Ashlesha Gogate, Vivian S. Park, Sijia Tao, Justin A. Ling, Ryohei Chiba, Hiroyoshi Matsumura, Ryo Uehara, Jonathan M. Fogg, Lynn Zechiedrich, Raymond F. Schinazi, Zachary F. Pursell, Abdulmelik Mohammed, Patricia L. Opresko, Bret D. Freudenthal, Baek Kim, Soojin V. Yi, Nataša Jonoska, Francesca Storici·· 2026-08-28评分53
人类核糖体组揭示DNA嵌入核糖核苷酸作为转录相关DNA超螺旋的表观遗传调节因子
Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
导读
人类核糖体组研究发现，DNA嵌入核糖核苷酸在启动子相关调控元件处积累并与转录活性成正比。RNase H2和Top1处理这些核糖核苷酸以调节DNA超螺旋，揭示了一种先前未被认识的转录相关表观遗传机制。
来源：Cell · cell.com