Cell· Raleigh M. Linville, Benjamin T. James, Kyriaki Galani, Li-Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B. Fass, James C. Cameron, Brent E. Fitzwalter, Roland Bock, Erin M. Murray, Mathilde Louçã, Oluwamayowa Oke, Charlotte Wang, Erica Engelberg-Cook, Michael DeTure, Vanessa Farrell, Sergio Sebastian Pineda, Suphinya Sathitloetsakun, Xinyue Liang, Bertha Madras, Dennis W. Dickson, Deborah C. Mash, Gustavo Turecki, Vanessa C. Wheeler, Veronica A. Alvarez, Dana Gabuzda, Manolis Kellis, Myriam Heiman·· 2026-09-01评分54
跨物种纹状体单细胞图谱揭示细胞类型与亚区疾病易感性
Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities
导读
研究通过人和小鼠纹状体的单核 RNA 测序与空间验证，定义了跨细胞类型、亚区和物种的神经元特化原则。这些发现为理解细胞和亚区分辨率下对脑功能与疾病的贡献奠定基础，包括成瘾风险、抗精神病药物反应、亨廷顿病易感性及药理学相关物种差异。
来源：Cell · cell.com