Science· Blaise L. Mariner, Brianah M. McCoy, Ashlee Greenier, Layla Brassington, Elizabeth Slikas, Christine Adjangba, Claire Cheng, Abbey Marye, Benjamin R. Harrison, Tal Bamberger, Yadid Algavi, Efrat Muller, Adam Harris, Emily Rout, Cindy Reichel, Vista Sohrab, The Dog Aging Project Consortium‡, Elinor Karlsson, Joshua M. Akey, Anne C. Avery, Elhanan Borenstein, Daniel E. L. Promislow, Noah Snyder-MacklerJoshua M. Akey, Rozalyn M. Anderson, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Matthew D. Dunbar, Virginia R. Fajt, Jessica M. Hoffman, Erica C. Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jing Ma, Evan L. MacLean, Stephanie McGrath, Natasha J. Olby, Daniel E.L. Promislow, May J. Reed, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, Noah Snyder-Mackler, M. Katherine Tolbert·· 15 小时前精选评分67
表观遗传衰老与转座子失调反映犬体型相关的寿命压缩
Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs
导读
2026年10月Science发表的Dog Aging Project研究在犬中分析表观遗传衰老与转座子失调，发现两者共同反映体型相关的寿命压缩现象。
推荐理由
原文以犬为模型把体型、寿命与表观遗传衰老联系在一起，为跨物种衰老机制研究提供可参照的分子表型。
来源：Science · science.org