Cell· Jessenya Mil, Jose A. Soto, Abigail S. Krall, Julia Peloggia, Sara Frigui, Olivia S. Fong, Laila Sathe, Nedas Matulionis, Francesca Day, Linsey Stiles, Katrina P. Montales, Daria J. Azizad, Carlos E. Gonzalez, Elisa Fazzari, Matthew X. Li, Patricia R. Nano, Antoni A. Martija, Cesar A. Perez-Ramirez, Claudia V. Nguyen, Brittney Wick, Weihong Ge, Ryan L. Kan, Madeline G. Andrews, Maximilian Haeussler, Michael F. Wells, Heather R. Christofk, Aparna Bhaduri·· 2026-08-04评分49
早期人类大脑皮层代谢图谱揭示糖酵解重塑与磷酸戊糖途径对细胞命运转换的调控
Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions
导读
研究绘制了发育中人类大脑皮层的代谢图谱，揭示糖酵解和磷酸戊糖途径活性是调控放射状胶质细胞命运的关键因素。这两种代谢途径控制着外层放射状胶质细胞和抑制性神经元的生成。该图谱为理解代谢在皮层发育中的关键作用提供了新视角。
来源：Cell · cell.com