Neonatal Gut Microbiota Propionate May Protect Against Later Asthma via GPR41
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Research from Hiroshi Ohno's team points to a early-life mechanism linking the gut microbiome to airway health. The human body carries roughly 40 trillion bacteria, mostly in the colon, and sequencing shows their composition differs in asthma and other immune and metabolic diseases. Multi-omics analysis spanning genomes, transcriptomes, proteins and metabolites indicates that propionate produced by gut microbiota in the neonatal window is received by GPR41-high cells associated with ILC2 and eosinophils in the small intestinal lamina propria and lung, upregulating genes such as kindlin and suppressing later airway inflammation. The protective imprint is set mainly in the neonatal period, with effects emerging later in life, after about age 5 in humans. The findings suggest early microbiota intervention could offer a time window for asthma prevention; full mechanistic details await the original paper.
Written by a model from the reports · updated 3 hours ago
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- YouTubeNeonatal Gut Microbiota Propionate Suppresses Later Airway Inflammation via GPR41 (Hiroshi Ohno)
The human body carries about 40 trillion bacteria, mostly in the colon, and NGS/16S sequencing shows their composition differs in asthma and other immune and metabolic diseases. Using multi-omics spanning genomes, transcriptomes, proteins and metabolites, the team found that propionate from gut microbiota in the neonatal window is received by GPR41-high cells (ILC2/eosinophil-associated) in the small intestinal lamina propria and lung, upregulating genes such as kindlin and suppressing later airway inflammation. The propionate-GPR41 axis sets a protective imprint mainly in the neonatal period, with effects emerging later in life (after about age 5 in humans), suggesting early microbiota intervention may be a time window for asthma prevention. The video is a lecture excerpt; final mechanistic details should be checked against the original paper.
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