Microfluidic Platform Screens Three-Drug Ratios for Pediatric Leukemia in Three Days
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A microfluidic platform called GradientScreen, developed by Wilbur A. Lam's group at Georgia Institute of Technology and Emory University, screens three-drug combination ratios for pediatric acute lymphoblastic leukemia within three days. The device generates overlapping drug gradients and characterizes overall efficacy (Emax), potency synergy, and efficacy synergy of three-drug combinations in a ratio-dependent manner. Because it works with limited samples, the method can achieve stable ratio-defined three-drug exposure for drug response screening in relapsed or refractory patients. The platform has been demonstrated as reported; clinical adoption and validation in larger patient cohorts are still open questions.
Written by a model from the reports · updated 3 hours ago
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- mp.weixin.qq.comGradientScreen Microfluidic Platform Screens Three-Drug Ratios for Pediatric Acute Lymphoblastic Leukemia in Three Days
The GradientScreen microfluidic platform, developed by Wilbur A. Lam's group at Georgia Institute of Technology and Emory University, screens three-drug combination ratios for pediatric acute lymphoblastic leukemia in three days. The platform uses a microfluidic device to generate overlapping drug gradients and characterizes overall efficacy (Emax), potency synergy, and efficacy synergy of three-drug combinations in a ratio-dependent manner. With limited samples, the method achieves stable ratio-defined three-drug exposure for drug response screening in relapsed or refractory patients.
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