Li Feng Team Shows PAK4 Kinase Promotes Exosome Release to Deepen Melanoma Immunosuppression
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A team led by Feng Li at China Medical University, with Ruizhi Zhou as first author, reports in PNAS that PAK4 kinase intensifies melanoma immunosuppression through a dual mechanism that boosts exosome secretion. It phosphorylates ANXA2 at Ser26 in a kinase activity-dependent manner to promote multivesicular body docking, and retains TRIM21 in the nucleus independently of kinase activity, stabilizing SYT1 to support SNARE complex assembly and membrane fusion.
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- WeChatPickLi Feng Team Shows PAK4 Kinase Promotes Exosome Release to Deepen Melanoma Immunosuppression
A team led by Feng Li at China Medical University, with Ruizhi Zhou as first author, reports in PNAS that PAK4 kinase intensifies melanoma immunosuppression through a dual mechanism that boosts exosome secretion. It phosphorylates ANXA2 at Ser26 in a kinase activity-dependent manner to promote multivesicular body docking, and retains TRIM21 in the nucleus independently of kinase activity, stabilizing SYT1 to support SNARE complex assembly and membrane fusion.
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