Biopharma's six biggest crossover rounds ever, led by Kailera's $600 million Series B
Start here
BioSpace and PitchBook have compiled the six largest crossover financings in biopharma history, spanning rounds raised by companies transitioning from private to public backing ahead of IPOs. Kailera Therapeutics' $600 million Series B tops the list. Three of the six largest rounds closed in 2025, a year in which crossover financing across biopharma totaled $3.83 billion. The compilation highlights how late-stage private investors are continuing to place large bets on clinical-stage drug developers. The full ranking, and the context around each deal, is laid out in the report.
Written by a model from the reports · updated 2 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- BioSpacePickThe 6 biggest crossover rounds in biopharma history
BioSpace, together with PitchBook, reviews the six largest crossover rounds in biopharma history. 2025 contributed three of them, and the year's crossover total reached $3.83 billion.
Coverage and heat for this story
Reports so far 1·Heat now 10·Peak heat 10 (Oct 21 13:00)·Reports, 24h +1
Two panels, same clock (pointer stays in sync): top is cumulative editorial reports — only rises; last point = All reports; slope = new reports that hour. Bottom is Live-board heatIndex — 7-day participants with a 24-hour half-life, so it can fall when talk cools.
