Guangzhou Laboratory Finds SOX2 Condensates Drive Chemo Resistance in Lung Squamous Cancer, Designs Peptide Hx1R8
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Hongjie Yao's group at Guangzhou National Laboratory reports in Signal Transduction and Targeted Therapy that a prion-like domain (PrLD) in SOX2 drives liquid-liquid phase separation to form condensates. These condensates directly bind and sequester chemotherapy drugs and weaken the DNA damage response, producing broad chemotherapeutic resistance in lung squamous cell carcinoma (LSCC).
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Hongjie Yao's group at Guangzhou National Laboratory reports in Signal Transduction and Targeted Therapy that a prion-like domain (PrLD) in SOX2 drives liquid-liquid phase separation to form condensates. These condensates directly bind and sequester chemotherapy drugs and weaken the DNA damage response, producing broad chemotherapeutic resistance in lung squamous cell carcinoma (LSCC).
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