SMaHT Network publishes first body-wide map of human somatic mosaicism
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The SMaHT Network has released benchmarked analysis tools along with the first body-wide map of somatic mosaicism, the acquired genetic variation that accumulates in cells after fertilization. The map establishes a baseline of what "normal" somatic variation looks like across human tissues, a reference point that has been missing until now. With this baseline in place, researchers can begin testing how somatic mosaicism contributes to development, aging, and disease. The work, published in Cell on October 22, 2026, is now available to the research community. Open questions include how mosaic variation differs across individuals and tissues and which variants drive disease rather than representing harmless background noise.
Written by a model from the reports · updated 3 hours ago
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- CellPickCharting the silent variation within us.
The SMaHT Network has released benchmarked tools and the first body-wide map of somatic mosaicism, establishing a baseline of 'normal' somatic variation so its roles in development, aging, and disease can be tested.
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