Passegué Details How Inflammaging Skews Aged Hematopoietic Stem Cells Toward Myeloid Output
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In a Cold Spring Harbor Laboratory Leading Strand lecture on YouTube, Emmanuelle Passegué laid out mechanisms of hematopoietic stem cell aging. She described how the bone marrow niche changes with age, with stromal and endothelial cells secreting pro-inflammatory factors during inflammaging that skew HSC output toward myeloid lineages. Heterochronic transplant and parabiosis experiments indicate HSC aging is cell-intrinsic. She pointed to candidate interventions: dampening niche inflammation, partial epigenetic reprogramming, and remodeling senescent cell metabolism. Clinical goals include improving erythropoiesis and vaccine responses and preventing clonal hematopoiesis from progressing to leukemia.
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- youtube.comEmmanuelle Passegué Explains Hematopoietic Stem Cell Aging and Inflammaging Mechanisms
In a Cold Spring Harbor Laboratory Leading Strand expert lecture on YouTube, Emmanuelle Passegué explains how the bone marrow niche changes with age, with stromal and endothelial cells secreting pro-inflammatory factors during inflammaging that skew hematopoietic stem cell output toward myeloid lineages. She notes that heterochronic transplant and parabiosis experiments show HSC aging is cell-intrinsic, and points to interventions including dampening niche inflammation, partial epigenetic reprogramming, and remodeling senescent cell metabolism. Clinical goals include improving erythropoiesis, vaccine responses, and preventing clonal hematopoiesis from progressing to leukemia.
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