Emmanuelle Passegué Explains Hematopoietic Stem Cell Aging and Inflammaging Mechanisms

In a Cold Spring Harbor Laboratory Leading Strand expert lecture on YouTube, Emmanuelle Passegué explains how the bone marrow niche changes with age, with stromal and endothelial cells secreting pro-inflammatory factors during inflammaging that skew hematopoietic stem cell output toward myeloid lineages. She notes that heterochronic transplant and parabiosis experiments show HSC aging is cell-intrinsic, and points to interventions including dampening niche inflammation, partial epigenetic reprogramming, and remodeling senescent cell metabolism. Clinical goals include improving erythropoiesis, vaccine responses, and preventing clonal hematopoiesis from progressing to leukemia.