ribociclib
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A community-discussed case describes a patient with de novo multimetastatic luminal A pleomorphic lobular breast cancer who achieved an exceptional response to treatment with ribociclib and letrozole. PET scans taken before and after treatment were shared, illustrating the extent of the response across multiple metastatic sites. The case, surfaced in a Reddit discussion dated 25 October 2026, is a single-patient observation rather than a trial result, so nothing can yet be generalized about durability, broader applicability, or how typical such responses are in pleomorphic lobular disease. Whether the response is ongoing, what the prior treatment history was, and how the case fits with existing evidence on this drug class in lobular subtypes remain open questions.
Written by a model from the reports · updated 4 hours ago
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Heat now 19·Peak in the comparable set 21 (Oct 26 04:00)·Change over 24h in the comparable set -5%·Participants now 4
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