Jiangnan University Team Links Bifidobacterium Gene Clusters to Constipation Relief
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Ji Chao, a researcher at Jiangnan University, presented an ImmuneZoom lecture covering probiotics, gut microbiota and food science, including work on functional gene clusters in Bifidobacterium. His lab identified clusters such as ABFA and HPA and showed that knocking out the ABFA cluster weakens Bifidobacterium's constipation-relieving effect, while the cluster's abundance can serve as a biomarker for constipation and metabolic phenotypes. The programme combines multiple clinical trials with a Cell Genomics paper, and bioinformatically predicted interaction pathways between food components, probiotics and human phenotypes have been validated in wet-lab experiments. The lecture, delivered on 2026-10-17, outlines an approach that ties probiotic function to specific genetic features rather than strain-level identity.
Written by a model from the reports · updated 2 hours ago
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- youtube.comJiangnan University Lecture Maps Bifidobacterium Gene Clusters to Constipation Relief and Metabolic Biomarkers
Jiangnan University researcher Ji Chao presented an ImmuneZoom lecture on probiotics, gut microbiota and food science, including functional gene clusters in Bifidobacterium. His lab identified clusters such as ABFA and HPA; knocking out the ABFA cluster weakens the constipation-relieving effect, and its abundance can serve as a biomarker for constipation and metabolic phenotypes. The work includes multiple clinical trials, a Cell Genomics paper, and bioinformatically identified interaction pathways between food components, probiotics and human phenotypes validated by wet-lab experiments.
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