B1-like innate B cells found in adult human organs at rest
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A study published in Science Immunology on October 24, 2026 reports that B1-like innate B cells persist in adult human organs during homeostasis. The researchers identified these cells within the IgM+ and IgA+ memory compartments across multiple adult organs, and their transcriptional profile more closely resembled murine and human prenatal B1 cells than marginal-zone B cells. The cells expressed markers including AHNAK and spontaneously secreted IgM. B-cell receptor sequencing of paired kidney and spleen samples showed that kidney IgM and IgA clones carried lower diversity and fewer mutations, suggesting the cells can seed organs independently of the spleen. The findings establish that a prenatal-like innate B cell population survives into adult life in humans.
Written by a model from the reports · updated 3 hours ago
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- Sci ImmunolB1-like innate B cells are present in adult human organs in homeostasis.
The study identified B1-like cells in the IgM+ and IgA+ memory compartments across multiple adult human organs. Their transcriptional profile was closer to murine and human prenatal B1 cells than to MZ B cells. B1-like cells expressed markers such as AHNAK and spontaneously secreted IgM; BCR sequencing of paired kidney and spleen samples showed lower clonal diversity and mutation rates in kidney IgM/IgA clones, suggesting spleen-independent seeding.
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