Nature Medicine flags image concerns in 2007 microRNA-133 cardiac hypertrophy paper
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Nature Medicine has issued an Editorial Expression of Concern over a 2007 paper reporting that microRNA-133 controls cardiac hypertrophy. The statement cites apparent image duplications: in Figure 1c, ventricle lanes 1 and 2 of the miR-133 and tRNAMet blots appear highly similar, and atria lane 1 resembles some ventricle bands; in Figure S2c, miR-1 and tRNAMet ventricle lanes 1 and 2 are likewise highly similar. Because the article is old, the original underlying data are no longer available, preventing further verification. Readers are advised to interpret the paper's findings with caution. The expression of concern is the current formal status of the paper; whether further editorial action follows is unresolved.
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Nature Medicine has issued an Editorial Expression of Concern over image concerns in a 2007 paper on MicroRNA-133 controlling cardiac hypertrophy. The statement notes that in Fig. 1c, Ventricles lanes 1 and 2 appear highly similar in both the miR-133 and tRNAMet blots, and Atria lane 1 also resembles some ventricle bands; in Fig. S2c, miR-1 and tRNAMet Ventricles lanes 1 and 2 are likewise highly similar. The original data are no longer available due to the age of the article, and readers are advised to interpret these data with caution.
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