Jenny Ting Maps NLR Family's Reach From Inflammasomes Into Adaptive Immunity
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In a 59-minute GLOBAL IMMUNOTALKS lecture, the second in an expert interpretation series hosted on YouTube, Jenny Ting's laboratory argued that the NLR family of proteins — roughly 20 members in humans and 30 in mice — does far more than form classic inflammasomes and drive Caspase-1-dependent IL-1 cytokine release. The talk traced how NLRs and related sensors shape adaptive immunity, including AIM2's effect on regulatory T cell stability, where RAC1 recruits PP2A to dephosphorylate AKT, and ZBP1-mediated necroptosis and apoptosis during SARS-CoV-2 infection that amplifies IL-1 signaling. The lecture lays out a framework connecting innate sensing to downstream adaptive immune outcomes.
Written by a model from the reports · updated 2 hours ago
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- youtube.comTing Lecture Explores How NLR Family and Inflammasomes Bridge Innate and Adaptive Immunity
In a 59-minute GLOBAL IMMUNOTALKS lecture, Jenny Ting's laboratory discussed how the NLR family, roughly 20 members in humans and 30 in mice, extends beyond classic inflammasome formation and Caspase-1-driven IL-1 cytokine release to regulate adaptive immunity. The talk covered AIM2 effects on Treg stability, where RAC1 recruits PP2A to dephosphorylate AKT, and ZBP1-mediated necroptosis and apoptosis during SARS-CoV-2 infection that amplifies IL-1 signaling. The lecture was the second in the expert interpretation series hosted on YouTube.
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