Ting Lecture Explores How NLR Family and Inflammasomes Bridge Innate and Adaptive Immunity

In a 59-minute GLOBAL IMMUNOTALKS lecture, Jenny Ting's laboratory discussed how the NLR family, roughly 20 members in humans and 30 in mice, extends beyond classic inflammasome formation and Caspase-1-driven IL-1 cytokine release to regulate adaptive immunity. The talk covered AIM2 effects on Treg stability, where RAC1 recruits PP2A to dephosphorylate AKT, and ZBP1-mediated necroptosis and apoptosis during SARS-CoV-2 infection that amplifies IL-1 signaling. The lecture was the second in the expert interpretation series hosted on YouTube.