Multimodal In Vivo Pooled Screening Platform Uncovers Liver Function Regulators

Researchers have developed a platform for multimodal in vivo pooled genetic screens and used it to identify regulators of liver function. Unlike conventional pooled screens, which typically rely on a single survival-based readout in cells, the platform measures multiple molecular and functional phenotypes directly in living animals, allowing each gene perturbation to be characterized along several dimensions at once. Applied to the liver, the approach surfaced genes that influence hepatic function, providing candidate targets and a reusable method for probing organ biology in vivo. The work was presented and discussed in an expert commentary on October 23, 2026. Open questions include which of the identified regulators have causal roles in liver disease, how the platform performs in other tissues, and whether the candidates translate into therapeutic targets.

Written by a model from the reports · updated 2 hours ago