Stellate cell Plvap knockout in mice rewires fasting liver energy metabolism
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A study in mice with a hepatic stellate cell-specific conditional knockout of Plvap found that HSC PLVAP regulates hepatic insulin signaling and the liver's energy substrate preference during fasting. Knocking it out redistributed fatty acids to skeletal muscle and improved glucose tolerance, while the conditional approach avoided confounding phenotypes such as the gut leakage seen with global knockout. The effect is context-dependent: it is reversed by high-fat, high-fructose overnutrition. The researchers position PLVAP as a potential research target for fatty liver, diabetes and other metabolic diseases. Translation of these mouse findings to human biology and any therapeutic application remains untested.
Written by a model from the reports · updated 4 hours ago
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- mp.weixin.qq.comHepatic stellate cell-specific Plvap knockout reveals fasting liver energy metabolism mechanism
A study in mice with hepatic stellate cell-specific Plvap conditional knockout found that HSC PLVAP regulates hepatic insulin signaling and energy substrate preference during fasting. Knockout redistributed fatty acids to skeletal muscle and improved glucose tolerance; the conditional approach avoided confounding phenotypes such as gut leakage seen with global knockout. The effect is context-dependent and reversed by high-fat, high-fructose overnutrition, making PLVAP a potential research target for fatty liver, diabetes and other metabolic diseases.
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