Marcelo Torres maps disease tolerance, microbial load and IL-10 deficiency in IBD
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Marcelo Torres of the Federal University of Rio de Janeiro delivered a 50-minute Global ImmunoTalks lecture on disease tolerance in inflammatory bowel disease. He drew a distinction between resistance, which clears pathogens, and tolerance, which limits tissue damage at a given microbial load. Using IL-10/IL-10R deficient mice that develop an IBD-like phenotype, he showed through co-housing experiments that a microbiome component can transfer disease. His group has also examined heme-driven inflammation mediated by immune receptors and reactive oxygen species in intracellular defense. The lecture lays out a framework for separating pathogen clearance from tissue-damage control in IBD, but how these mechanisms translate to human disease is not yet resolved.
Written by a model from the reports · updated 2 hours ago
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- youtube.comGlobal ImmunoTalks: Marcelo Torres on Disease Tolerance, Microbial Load and IL-10 Deficiency in IBD
Marcelo Torres of the Federal University of Rio de Janeiro gave a 50-minute Global ImmunoTalks lecture on disease tolerance in inflammatory bowel disease. He distinguished resistance, which clears pathogens, from tolerance, which limits tissue damage at a given microbial load, and described how IL-10/IL-10R deficient mice develop an IBD-like phenotype. Co-housing experiments showed a microbiome component can transfer disease; his group has also studied heme-driven inflammation via immune receptors and ROS in intracellular defense.
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