Wei Wang Lab Maps Chromatin Remodeling Driving Fin Regeneration in Fish
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A study published in Science Advances by the Wei Wang lab at the National Institute of Biological Sciences, Beijing and Tsinghua University shows that damage-induced remodeling of three-dimensional chromatin architecture controls key gene expression during fin regeneration. Using the Micro-C technique, the researchers systematically compared genome organization before and after tail fin regeneration in two species, zebrafish and African killifish, revealing how injury reshapes chromatin architecture and in turn regulates the genes required for regrowth. The work establishes a comparative framework for studying regeneration across species and points to chromatin dynamics as a regulatory layer in tissue repair.
Written by a model from the reports · updated 3 hours ago
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- mp.weixin.qq.comWei Wang Lab Shows Damage-Induced Chromatin Architecture Remodeling Controls Key Gene Expression in Fish Fin Regeneration in Science Advances
The Wei Wang lab at the National Institute of Biological Sciences, Beijing and Tsinghua University published a study in Science Advances. Using Micro-C, the team systematically compared three-dimensional genome dynamics before and after tail fin regeneration in zebrafish and African killifish.
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