MicroRNA networks across pediatric brain tumors shape immune states and CAR T responses
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A preprint posted on bioRxiv in Cancer Biology on October 23, 2026 analyzes pediatric central nervous system tumors by integrating small RNA and bulk transcriptomic data across four tumor types: diffuse midline glioma, medulloblastoma, ependymoma, and low-grade glioma. The work identifies microRNA networks connected to immune programs including T-cell activity, natural killer cells, antigen presentation, and myeloid signatures. By mapping these networks, the study links tumor microenvironment states to responses to CAR T-cell therapy. The findings have not yet undergone peer review. What remains open is validation of the identified microRNA networks in independent cohorts and whether they can guide patient selection or combination strategies for CAR T-cell therapy in pediatric brain tumors.
Written by a model from the reports · updated 3 hours ago
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- biorxiv.orgPan-pediatric brain tumor microRNA networks define immune microenvironment states and responses to CAR T-cell therapy
A preprint on pediatric central nervous system tumors integrates small RNA and bulk transcriptomic data from diffuse midline glioma, medulloblastoma, ependymoma, and low-grade glioma, identifying miRNA networks linked to T-cell, natural killer cell, antigen presentation, and myeloid programs.
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