Aged mouse fathers alter embryonic brain gene expression in female offspring only
Start here
A developmental neuroscience team at Tohoku University used RNA sequencing to compare gene expression in the embryonic telencephalon of offspring born to young (3-month-old) and aged (19-month-old) male mice. Female embryos fathered by aged males showed a distinct transcriptional profile with a tendency toward upregulated expression. To rule out timing effects, the researchers controlled developmental stage to a window of roughly four hours based on limb morphology. Published in Scientific Data, the study provides a dataset resource for investigating how advanced paternal age might shape early brain development and contribute to sex differences observed in autism spectrum disorder. How these transcriptional changes translate into later neural or behavioral outcomes remains an open question.
Written by a model from the reports · updated 3 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- Medical XpressAdvanced paternal age has sex-specific effects on fetal brain gene expression, mouse study suggests
A Tohoku University developmental neuroscience team used RNA sequencing to compare gene expression in the embryonic telencephalon of offspring of young (3-month-old) and aged (19-month-old) male mice. Female embryos from aged fathers showed a distinct transcriptional profile with a tendency toward upregulated expression. Developmental timing was controlled within an approximately four-hour window based on limb morphology to reduce variability. The data, published in Scientific Data, provide a resource for exploring molecular links between advanced paternal age, early brain development, and sex differences in autism spectrum disorder.
Coverage and heat for this story
Reports so far 1·Heat now 6·Peak heat 10 (Oct 20 02:00)·Reports, 24h +1
Two panels, same clock (pointer stays in sync): top is cumulative editorial reports — only rises; last point = All reports; slope = new reports that hour. Bottom is Live-board heatIndex — 7-day participants with a 24-hour half-life, so it can fall when talk cools.