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ipilimumab

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At the data cutoff of June 19, 2026, the single-arm, multicentre phase 2 NICHE-2 trial showed that neoadjuvant ipilimumab plus nivolumab in locally advanced mismatch repair-deficient colon cancer achieved a 3-year disease-free survival of 100% (97.5% CI 100-100) and an exploratory 5-year overall survival of 100% (95% CI 100-100).

Excerpted from Lancet

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Oct 23
  1. Lancet
    Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.

    At the data cutoff of June 19, 2026, the single-arm, multicentre phase 2 NICHE-2 trial showed that neoadjuvant ipilimumab plus nivolumab in locally advanced mismatch repair-deficient colon cancer achieved a 3-year disease-free survival of 100% (97.5% CI 100-100) and an exploratory 5-year overall survival of 100% (95% CI 100-100).

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Heat now 11·Peak in the comparable set 19 (Oct 23 23:00)·Change over 24h in the comparable set +158%·Participants now 3

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