PVT1 promoter acts as a tumor-suppressor DNA boundary element, Cell study finds
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Research published in Cell (volume 173, pages 1398–1412, dated May 31, 2018) reports that the promoter of the long non-coding RNA gene PVT1 functions as a tumor-suppressor DNA boundary element. The finding assigns a cancer-suppressing role to the DNA element that controls PVT1 transcription, distinct from any function of the PVT1 RNA product itself. The work situates the PVT1 locus, which lies adjacent to the MYC oncogene region, within the mechanisms that restrain tumor growth. Detailed results, methods and implications remain available only in the full paper, which this page does not yet summarize in depth.
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- CellPickPromoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
The item is a research paper published in Cell on May 31, 2018, in volume 173, pages 1398-1412. Its title states that the promoter of the lncRNA gene PVT1 functions as a tumor-suppressor DNA boundary element; the feed did not provide the full text. Link: https://www.cell.com/cell/fulltext/S0092-8674(26)01266-3
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