doi.org· The Journal of experimental medicine·· 21 hours agoPickScore72
Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses
In brief
Colorectal cancers with different metastatic potential induce different early T cell responses: nonmetastatic tumors trigger cytotoxic and Th1-like programs, while pro-metastatic tumors leave T cells in a naïve-like, hypoactivated state. Using orthotopic organoid transplantation and T cell fate-mapping, the study found that pro-metastatic tumors downregulate MHCII, and targeting Ciita weakened CD4+ clonal expansion in nonmetastatic organoids and promoted tumor progression.
Why it matters
Using orthotopic organoid transplantation and T cell fate-mapping, the study contrasted early immune responses to nonmetastatic and pro-metastatic tumors and identified MHCII downregulation as the mechanistic difference.
