biorxiv.org· Jeong, M., Liu, Z., Ni, J., An, U., Han, S., Anand, A., Anand, P., Boffelli, M., Sankararaman, S. ·· 13 hours agoPickScore56
Genome-wide LD scores enable robust heritability and genetic correlation estimation from summary statistics across genetic ancestries
Genome-wide LD scores enable robust heritability and genetic correlation estimation from summary statistics across genetic ancestries
In brief
SUMMIT is a statistical framework that combines genome-wide LD scores with GWAS summary statistics to estimate genome-wide and annotation-specific heritability and genetic correlation in European, South Asian, and admixed African-European populations.
Why it matters
Improves heritability and genetic correlation estimation accuracy in non-European and admixed populations, offering a methodological reference for similar studies.
Source: biorxiv.org · biorxiv.org