mp.weixin.qq.com·· 7 hours agoPickScore79
Nature Paper Screens 8,448-Cyclic Peptide Library for High-Affinity Thrombin Binders
In brief
A Nature study synthesized a library of 8,448 cyclic peptides and screened it against thrombin, yielding cyclic peptides with nanomolar affinity and high stability. The workflow supports multiple rounds of iterative library synthesis, and the resulting peptides achieved rat oral bioavailability (%F) of up to 18%.
Why it matters
Iterative synthesis and screening of an 8,448-member cyclic peptide library produced peptides with nanomolar affinity, high stability and up to 18% oral bioavailability in rats.
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